Research behind the formula

Rhodiola is one of the more widely studied adaptogenic herbs for stress and fatigue. In a randomized, placebo-controlled trial, adults with stress-related fatigue who took a standardized Rhodiola extract for 28 days reported less burnout and improved mental performance, alongside a more favourable cortisol response to waking stress, compared with placebo.

Vitamin B6 (pyridoxine) is a cofactor in over 100 enzyme reactions, including those involved in glycogen breakdown and energy release. A 2026 review in the World Journal of Men's Health summarized the mechanistic evidence linking vitamin B6 status to testosterone production and regulation, including its role in hormonal signalling pathways and energy metabolism.

Vitamin D deficiency is common and has been linked to lower testosterone levels. In a double-blind, placebo-controlled trial, men with both low vitamin D and low testosterone at baseline received 20,000 IU of vitamin D3 per week for 12 weeks; the study examined whether correcting vitamin D status could support healthier testosterone levels in this deficient group.

Boron is a trace mineral studied for its role in steroid hormone metabolism. Research has examined daily boron supplementation in men and observed changes in free testosterone and estradiol levels alongside markers of inflammation, though study sizes have generally been small and further long-term research has been called for.

Magnesium is a cofactor in hundreds of enzymatic reactions, including those involved in muscle and nerve function. A four-week supplementation study in both sedentary men and athletes found increases in free and total testosterone following magnesium supplementation, with a larger effect observed in those who exercised regularly.

Zinc is an essential mineral involved in testosterone metabolism. In a landmark study, marginally zinc-deficient older men who supplemented with zinc for six months saw their serum testosterone levels roughly double, moving back into the normal range for healthy adults; a 2022 systematic review of the wider literature concluded that zinc deficiency lowers testosterone and that supplementation can help restore it.

Compounds (lignans) in nettle root have been studied for their interaction with sex hormone-binding globulin (SHBG), the protein that transports testosterone in the blood. Laboratory research identified this SHBG-binding mechanism, and a subsequent randomized, placebo-controlled crossover trial in men examined nettle root's effect on related urinary symptoms associated with age-related hormonal changes.

Vitamin K2 works alongside vitamin D to help direct calcium to bone rather than soft tissue, activating proteins involved in bone mineralisation and vascular health. A narrative review of the human evidence concluded that vitamin D and K together are associated with better outcomes for bone and cardiovascular health than either nutrient supplemented alone.